Combinatorial degradomics: Precision tools to unveil proteolytic processes in biological systems
نویسندگان
چکیده
منابع مشابه
Microarray tools to unveil viral-microbe interactions in nature
*Correspondence: Josefa Antón, Departamento de Fisiología, Genética y Microbiología, Universidad de Alicante, Apartado 99, 03080 Alicante, Spain e-mail: [email protected] The interactions between viruses and their microbial hosts play a central role in the control of microbial communities in nature. However, the study of such interactions within the uncultured majority is technically very challenging...
متن کاملIntegrated Modeling Tools for Precision Multidisciplinary Systems
An integrated modeling tool that couples structural, optical, thermal and control disciplines is discussed. Details of the core modules that comprise the tool are provided, and recent applications of the tool are given. Particular emphasis is on the modeling of precision optomechanical systems and how IMOS has been used to perform multidisciplinary analgsis of such sgstems.
متن کاملCooperativity in biological systems
Living organisms can sense and respond to external and internal stimuli. Response isdemonstrated in many forms including modulation of gene expression profiles, motility,secretion, cell death, etc. Nevertheless, all forms share a basic property: they depend on sensingsmall changes in the concentration of an effector molecule or subtle conformational changes ina protein and invoking the appropri...
متن کاملMetadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.
Post-translational modifications enable extra layers of control of the proteome, and perhaps the most important is proteolysis, a major irreversible modification affecting every protein. The intersection of the protease web with a proteome sculpts that proteome, dynamically modifying its state and function. Protease expression is distorted in cancer, so perturbing signaling pathways and the sec...
متن کاملTopological augmentation to infer hidden processes in biological systems
MOTIVATION A common problem in understanding a biochemical system is to infer its correct structure or topology. This topology consists of all relevant state variables-usually molecules and their interactions. Here we present a method called topological augmentation to infer this structure in a statistically rigorous and systematic way from prior knowledge and experimental data. RESULTS Topol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2020
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2020.140392